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At LAP&P we aim to contribute to scientific aspects of Modelling and Simulation in drug development. The following selection of papers, posters, and presentations were prepared by LAP&P and are available in open literature:
2007
van Steeg TJ, Freijer J, Danhof M, de Lange EC. Pharmacokinetic-pharmacodynamic modelling of S(-)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint. Br J Pharmacol. 2007 Jun;151(3):356-66.
[Link to publication]
Teun Post, Tomoo Funaki, Hiromi Maune, Henk-Jan Drenth. Circadian rhythm in pharmacodynamics and its influence on the identification of treatment effects. PAGE 16 (2007) Abstr 1098 (ORAL PRESENTATION).
[Link to publication]
Strougo A, Elassaiss-Schaap J, de Greef HJMM, Drenth H. Mechanism-based model of the effect of co-administration of exogenous testosterone and progestogens on the hypothalamic-pituitary-gonodal axis in men. PAGE 16 (2007) Abstr 1092 (ORAL PRESENTATION)
[Link to publication]
Peeters MY, Bras LJ, Dejongh J, Wesselink RM, Aarts LP, Danhof M, Knibbe CA. Disease Severity Is a Major Determinant for the Pharmacodynamics of Propofol in Critically Ill Patients. Clin Pharmacol Ther. 2007 Aug 8;
[Link to publication]
Danhof M, de Jongh J, De Lange EC, Della Pasqua O, Ploeger BA, Voskuyl RA. Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis. Annu Rev Pharmacol Toxicol. 2007;47:357-400. Review.
[Link to publication]
Anouk E. Muller, Joost DeJongh, Ymka Bult, Wil H.F. Goessens, Johan W. Mouton, Meindert Danhof, John N. van den Anker. Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. Antimicrob. Agents Chemother. doi:10.1128/AAC.00318-07, published online ahead of print on 23 July 2007.
[Link to publication]
2006
Freijer, J.I., T.M. Post, B.A. Ploeger, J. Dejongh and M. Danhof, Application of the Convection-Dispersion Equation to Modelling Oral Drug Absorption, Bull Math Biol , 6 : 6, 2006. [Link to publication]
De Winter, W., J. DeJongh, T. Post, B. Ploeger, R. Urquhart, I. Moules, D. Eckland and M. Danhof, A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus, J Pharmacokinet Pharmacodyn. , 33 : 313-43. Epub 2006 Mar 22., 2006. [Link to publication]
Peeters, M.Y., S.A. Prins, C.A. Knibbe, J. DeJongh, R.H. van Schaik, M. van Dijk, I.P. van der Heiden, D. Tibboel and M. Danhof, Propofol pharmacokinetics and pharmacodynamics for depth of sedation in nonventilated infants after major craniofacial surgery, Anesthesiology. , 104 : 466-74., 2006
Post, T.M.(1), J.I. Freijer (1), W. de Winter (1), B.A. Ploeger (1,2), Accurate Interpretation of the Visual Predictive Check in order to Evaluate Model Performance, PAGE 15 (2006) Abstr 972, POSTER. [Link to publication]
2005
Post, T.M., J.I. Freijer, J. DeJongh and M. Danhof, Disease system analysis: basic disease progression models in degenerative disease, Pharm Res. , 22 : 1038-49. Epub 2005 Jul 22., 2005. [Link to publication]
Jan Freijer, Inez de Greef - van der Sandt, Teun Post, Bart Ploeger, Robust fitting of pharmacokinetic models to Phase II/III clinical trial data, POSTER, PAGE 14 (2005) Abstr 751. [Link to publication]
2004 and older
Knibbe, C.A., K.P. Zuideveld, J. DeJongh, P.F. Kuks, L.P. Aarts and M. Danhof, Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients: a comparison between propofol 6% and propofol 1%, Clin Pharmacol Ther. , 72 : 670-84., 2002
B. Ploeger(2), N. Houwing(1), A. Bom(3), M.P. van Iersel(1), D. Zollinger(1), M. Danhof(2) The reversal of rocuronium-induced neuromuscular block by the cyclodextrin ORG25969: model development and validation, POSTER, PAGE 13 (2004) Abstr 473. [Link to publication]
Jan Freijer, Teun Post, Bart Ploeger, Joost DeJongh, Meindert Danhof, Modelling of drug absorption as a transport-limited process, POSTER, PAGE 12 (2003) Abstr 376. [Link to publication]
Jan Freijer, Bart Ploeger, Joost DeJongh & Meindert Danhof, Extrapolation of pharmacokinetics and toxicity from pre-clinical data to humans, ORAL PRESENTATION PAGE 11 (2002) Abstr 341. [Link to publication]