http://www.lapp.nl/ Recent publications and news of LAPP consultants en http://www.lapp.nl/typo3conf/ext/tt_news/ext_icon.gif http://www.lapp.nl/ 18 16 Recent publications and news of LAPP consultants TYPO3 - get.content.right http://blogs.law.harvard.edu/tech/rss Wed, 02 Nov 2011 10:09:00 +0100 http://www.lapp.nl/ Ackaert O., Rijn-Bikker P.v., Snelder N., Hest R.v., Ploeger B., Monfrans G.v., Koopmans R. and... Population modeling of blood pressure: assessing clinically important factors for cardiovascular diseases. PAGE.(2011) http://www.page-meeting.org/default.asp?id=35&keuze=abstract-view&goto=profile&profile_id=2177&abstract_id=2025 ]]> Presentations Wed, 02 Nov 2011 10:09:00 +0100 http://www.lapp.nl/ Snelder N., Ploeger B.A., Danhof M., Stanski D.R., Rigel D., Webb R., Feldman D. and Luttringer O.,... Quantitative understanding of drug effects on the interrelationship between mean arterial blood pressure, cardiac output and total peripheral resistance. PAGE.(2011) http://www.page-meeting.org/default.asp?id=35&keuze=abstract-view&goto=profile&profile_id=777&abstract_id=2058 ]]> Presentations Wed, 02 Nov 2011 10:08:00 +0100 http://www.lapp.nl/ Maanen E.V., Challenges in Non-Clinical Assessment of Antisense Oligonucleotides: Modelling... Challenges in Non-Clinical Assessment of Antisense Oligonucleotides: Modelling Perspectives. Oral presentation at the AAPS National Biotechnology Conference, 2011. http://www.aaps.org/Meeting_and_Professional_Development/past_meetings/Eline_van_Maanen_11NBC/ ]]> Presentations Wed, 02 Nov 2011 10:06:00 +0100 http://www.lapp.nl/ Diack C., Ackaert O., Ploeger B.A., Graaf P.H.v.d., Gurrell R., Ivarsson M. and Fairman D., A... J Pharmacokinet Pharmacodyn, 10: 10, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21909798 ]]> Publications Wed, 02 Nov 2011 10:04:00 +0100 http://www.lapp.nl/ Erp N.P.v., Guchelaar H.J., Ploeger B.A., Romijn J.A., Hartigh J. and Gelderblom H., Mitotane has a... Eur J Endocrinol., 164(4): 621-626. Epub 2011 Jan 2010., 2011. http://www.ncbi.nlm.nih.gov/pubmed/21220434 ]]> Publications Wed, 02 Nov 2011 10:03:00 +0100 http://www.lapp.nl/ Holford N., Ma S.C. and Ploeger B.A., Response to "validation and assessment of predictive... Clin Pharmacol Ther., 89(4): 488 (2011). http://www.ncbi.nlm.nih.gov/pubmed/21346756 ]]> Publications Wed, 02 Nov 2011 10:00:00 +0100 http://www.lapp.nl/ LAP&P consultants will be attending the 2011 AAPS annual meeting from October 23rd to 28th.... info@lapp.nl should you wish to meet us in Washington. We would be happy to discuss our Services with you.]]> News Wed, 19 Oct 2011 09:46:00 +0200 http://www.lapp.nl/ Eline van Maanen to present modeling of oligonucleotides info@lapp.nl, or browse to the contact page of our website. ]]> News Sun, 08 May 2011 22:13:00 +0200 http://www.lapp.nl/ Krekels E.H., Jongh J.d., Lingen R.A.v., Marel C.D.v.d., Choonara I., Lynn A.M., Danhof M., Tibboel... Jongh J.d., Lingen R.A.v., Marel C.D.v.d., Choonara I., Lynn A.M., Danhof M., Tibboel D. and Knibbe C.A., Predictive performance of a recently developed population pharmacokinetic model for morphine and its metabolites in new datasets of (preterm) neonates, infants and children, Clin Pharmacokinet., 50(1): 51-63, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21142267 ]]> Publications Tue, 25 Jan 2011 22:09:00 +0100 http://www.lapp.nl/ Eight of our consultants will attend the 2011 PAGE meeting from June 7-10 in Athens. Please feel... http://www.page-meeting.org/ ]]> News Tue, 25 Jan 2011 21:54:00 +0100 http://www.lapp.nl/ Our colleagues Henk-Jan Drenth and Joost de Jongh will attend the ACoP meeting in San Diego from... http://www.go-acop.org/ We look forward to meeting you in San Diego! ]]> News Tue, 25 Jan 2011 11:45:00 +0100 http://www.lapp.nl/ Stringer F., Jongh J.d, Ploeger B., Scott G., Urquart R. and Danhof M., Clinical impact of genetic... Clinical impact of genetic polymorphisms observed in the pharmacokinetics of the novel PPAR agonist, Sipoglitazar. Noordwijkerhout.(2010).]]> Presentations Mon, 29 Nov 2010 12:03:00 +0100 http://www.lapp.nl/ Snelder N., Ploeger B., Danhof M., Stanski D., Rigel D., Webb R., Feldman D. and Luttringer O.,... Drug effects on the Cardiovascular system – development of a mechanism-based pharmacodynamic model to improve translational drug research. Noordwijkerhout.(2010).]]> Presentations Mon, 29 Nov 2010 12:02:00 +0100 http://www.lapp.nl/ Jongh J.d. and Ploeger B., A population PD model for effects of the cytostatic drugs Irinotecan and... A population PD model for effects of the cytostatic drugs Irinotecan and Temozolomide on Rh18 rabdomyosarcoma xenografts in mice. Noordwijkerhout.(2010).]]> Presentations Mon, 29 Nov 2010 12:02:00 +0100 http://www.lapp.nl/ Maanen E. v., Brady K., Steeg T.v. and Graaf P.v.d., A novel integrated RNAi/viral dynamics systems... A novel integrated RNAi/viral dynamics systems pharmacology model to predict clinical efficacy of viral vector delivery of siRNA for the treatment of HCV. Noordwijkerhout.(2010).]]> Presentations Mon, 29 Nov 2010 12:01:00 +0100 http://www.lapp.nl/ Diack C., Ackaert O., Ploeger B., Graaf P.v.d., Gurrell R., Ivarsson M. and Fairman D., A... A true Markov model for sleep disturbance. PAGE.(2010).]]> Presentations Mon, 29 Nov 2010 12:00:00 +0100 http://www.lapp.nl/ Holford N., Ma S.C.and Ploeger B.A. Clinical Trial Simulation: A Review, Clin Pharmacol Ther. 7:7,... Ploeger B.A. Clinical Trial Simulation: A Review, Clin Pharmacol Ther. 7:7, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20613720]]> Publications Mon, 29 Nov 2010 11:44:00 +0100 http://www.lapp.nl/ Muller A.E., Mouton J.W., Oostvogel P.M., Dorr P.J., Voskuyl R.A., Jongh J.d., Steegers E.A. and... Jongh J.d., Steegers E.A. and Danhof M., The pharmacokinetics of clindamycin in pregnant women in the peripartum period, Antimicrob Agents Chemother, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20176904]]> Publications Mon, 29 Nov 2010 00:00:00 +0100 http://www.lapp.nl/ Our CEO, Henk-Jan Drenth, will attend the “PK-PD Modelling the Transition Phase” meeting from 7th –... Our CEO, Henk-Jan Drenth, will attend the “PK-PD Modelling the Transition Phase” meeting from 7th – 9th December 2010 in Frankfurt. The meeting will cover topics related to “Translating measurements from in vivo testing into the clinical phase”. LAP&P is specialised in providing M&S activities in this area. Many of our colleagues have a strong background in PBPK modelling and preclinical PK-PD modelling. In several projects, LAP&P has supported their clients in bringing preclinical knowledge forward into the clinical development. Modelling and Simulation provides a crucial tool to accomplish that challenging task.   If you happen to attend the PK-PD modelling the transition Phase meeting in Frankfurt, please feel free to contact Henk-Jan Drenth to learn more about LAP&P’s Services.]]> News Fri, 26 Nov 2010 22:23:00 +0100 http://www.lapp.nl/ Benson N, Snelder N, Ploeger B, Napier C, Sale H, Birdsall NJ, Butt RP, van der Graaf ... Br J Pharmacol. 2010 May;160(2):389-98.]]> Publications Thu, 20 May 2010 00:00:00 +0200